By Jeff Eckenrode

Quick Answer: RSO is a full-spectrum cannabis extract ideal for therapeutic use, while distillate is a purified, flavorless oil best for precise dosing, edibles, or vaping. Use RSO for whole-plant benefits and deeper relief; choose distillate for high potency with minimal taste. Each serves a different purpose depending on your needs.

RSO and distillate are two of the most popular cannabis concentrates on the market.

Both are potent, both are versatile, and both can be incredibly effective, depending on what you’re looking for.

But if you’re wondering which one to use (and when) there are a few key differences to keep in mind.

What Is RSO?

RSO, or Rick Simpson Oil, is a thick, tar-like extract made using the entire cannabis plant.

It’s typically dark in color, strong in flavor, and packed with more than just THC.

Because it’s made using a full-spectrum extraction method, RSO retains a wide range of cannabinoids, terpenes, chlorophyll, and other plant compounds.

In other words: RSO is about the whole plant experience.

It’s usually taken orally or applied topically. Some people use it for chronic pain, sleep, or general wellness. Others follow intensive regimens for more serious conditions.

Whatever your reason, one thing is true: RSO is strong, sticky, and not for the faint of heart.

What Is Distillate?

Distillate is almost the opposite of RSO in both look and feel. It’s a highly refined cannabis oil that’s been stripped down to its core ingredient—usually THC or CBD. The result is a clear, golden, odorless oil that’s nearly 100% pure cannabinoid.

Think of it as the isolated essence of cannabis.

Because it’s so neutral and versatile, distillate is often combined with cannabis or botanically derived terpenes for use in vape cartridges, edibles, or tinctures.

However, distillate has no distinct taste or smell on its own, so it blends well into recipes or formulas. If you’re looking for precision dosing and consistency from vape to vape, distillate is your go-to option.

Which One Should You Use?

It depends on what you need and how you plan to use it.

Use RSO if:

You want a full-spectrum experience

You’re using cannabis for deeper therapeutic purposes

You’re okay with strong taste and slower onset

You prefer swallowing or applying it topically

Use Distillate if:

You want precise, consistent dosing

You’re making edibles and don’t want a cannabis taste

You prefer vaping or discreet consumption

You want high potency with less of the “plant” feel

Can You Use Both?

Absolutely! Some people use RSO in the evening for rest and recovery, and distillate during the day for a clean, functional high. Others combine them for targeted effects.

There’s no wrong answer. Just different tools for different jobs.